In DEFA1/DEFA3 transgenic mice, increased gene copy numbers of DEFA1/DEFA3 worsen sepsis by inducing endothelial pyroptosis and vascular permeability in a canonical Nod-like receptor family pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome dependent manner [13]. Here, DEFA1 is linked to Sepsis.