NLRP3 and Sepsis: Furthermore, we observed that when exogenous HNP-1 was intraperitoneally administered into Nlrp3−/− and Casp1−/− mice 6 hours after sepsis, the survival of mice administered a high dose of HNP-1 was comparable to that of mice administered a low dose of HNP-1 or PBS (Figures 7(a) and 7(b)).