Additionally, we found that the plasma and PLF levels of IL-1β and IL-18 in Casp1−/− mice administered a high dose of HNP-1 after sepsis onset were not significantly decreased when compared to those in wild-type mice receiving a high dose of HNP-1 (Supplementary Figures 3(a)-3(d)). This evidence concerns the gene DEFA1 and Sepsis.