NR4A1 and osteoarthritis: Intra-articular (IA) administration of the NR4A1 agonist, Csn-B, reactivates and restores the anti-inflammatory effects of NR4A1, preventing excessive inflammation [through the repression of IL-1β-induced chondrocyte inflammation and expression of COX-2, iNOS, MMP-3, MMP-9, and MMP-13] and ameliorating cartilage degradation and osteoarthritis progression (103).