Cancer cells also require increased expression of CS proteins for dealing with other kind of stresses, such as oxidative and ER stresses, the latter responsible of the triggering of the Unfolded Protein Response (UPR), the adaptive survival strategy that cancer cells adopt to deal with the increasing levels of ER stress (Storz et al., 2005; Yadav et al., 2014). The gene discussed is CS; the disease is cancer.