In rodents, exogenous administration of NRG-1 reduces cerebral infarct size in middle cerebral artery occlusion (MCAO)-induced stroke and reduces white blood cell accumulation and inflammatory cytokine production (Simmons et al., 2016, Surles-Zeigler et al., 2018, Solomon et al., 2014, Xu et al., 2005). The gene discussed is NRG1; the disease is Stroke.