We have previously identified platelet derived growth factor type-AA (PDGF-AA) and brain derived neurotrophic factor (BDNF) as predictors of cerebral infarct and stroke risk in children with SCA (Hyacinth et al., 2014, Hyacinth et al., 2012, Lance et al., 2014). This evidence concerns the gene BDNF and autosomal dominant cerebellar ataxia.