Serum indicators have been used in the auxiliary diagnosis of T2DM-CHD, including creatine kinase (CK), hypersensitive C-reactive protein (hsCRP), cardiac troponin I, lactate dehydrogenase (LDH), NT-proBNP, homocysteine, and CKMB-mass (21–23). The gene discussed is NPPB; the disease is type 2 diabetes mellitus.