Accumulating evidence has shown that YAP/TAZ induce the expression of downstream target genes after binding with the transcription factors of the TEAD binding domain and then plays an vital role in angiogenesis, ECM remodeling and atherosclerosis by regulating cell proliferation and migration (7, 29, 39, 47, 64–68) (Table 1). Here, WWTR1 is linked to atherosclerosis.