Meantime, the expression of pro-inflammatory factors, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and interleukin-6 (IL-6) were increased (29, 34, 35), which led to vascular endothelial injury and atherosclerosis. This evidence concerns the gene ICAM1 and atherosclerosis.