MYOM2 and Miyoshi myopathy: In the present study, we have performed de novo sequencing on mass spectra to derive the M-protein sequence information directly from archived diagnostic SPEP gels without any RNAseq reference data.11 This study, which was approved by the institutional review board (MEC-2019-0342), demonstrates the feasibility of this approach on longitudinal samples of 9 MM patients, and demonstrates that the method allows for an earlier detection of relapses.