The typical half-life for IgG is about 21 to 25 days, and even after an immediate removal of myeloma cells, M-protein would be cleared no faster than that rate.13 The decreases seen in patients 2, 3, and 7 are consistent with such typical clearance for IgG, while faster clearance may be seen for other classes of M-protein (IgA). The gene discussed is MYOM2; the disease is plasma cell myeloma.