However, upon transplantation into NOD scid gamma (NSG) mice, Ctr cells exposed profound leukemia engraftment in the spleen (Sp; P = 0.0079), bone marrow (BM, P = 0.0079), and CNS (P = 0.0079) leading to sacrifice of all Ctr animals after 25 days while animals injected with CD79b-ITAM-KO cells did not show signs of leukemia at that timepoint (Figure 1A–C, Suppl. This evidence concerns the gene CD79B and leukemia.