Although the response against the N protein is important for the protection against SARS-CoV-2 infection, the inhibition observed in our research in HCWs who have developed a memory response against the S protein, induced by the vaccine, probably does not have a significant effect on protection against infection due to the great efficacy of the S protein memory response against SARS-CoV-2 [13]. Here, PROS1 is linked to infection.