MAPK8 and glioblastoma: In the meantime, it was observed that knockdown of SRPX2 decreased the MAPK signaling pathway (p-ERK, p-JNK, and p-p38) proteins, but blocking the MAPK signaling pathway by PD098059 inhibited glioblastoma metastasis, not cell invasion and migration in the cells with downregulation of SRPX2, suggesting that SRPX2 promoted the EMT process to enhance glioblastoma metastasis through the MAPK signaling pathway [18].