Compared with tumor tissues, the level of IFNγ, IL-12p40, Eotaxin-1, Eotaxin-2, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-10, IL-17, IL-21, TNFRII, G-CSF, TNFRI, CXCL4, and LIX increased in the serum over twofold after rAd-mIL-28B treatment (Figure 4(h)). Here, IL21 is linked to neoplasm.