There were significant differences in education, smoking, alcohol consumption, type of mental disorder, age at onset of the mental disorder, duration of the mental disorder, duration of treatment for the mental disorder, duration of treatment with antipsychotic drugs, use of antipsychotic drugs, use of clozapine, use of cholinesterase inhibitors, CCI and incidences of comorbid diseases (cerebrovascular disease, CVD, diabetes mellitus) between the CAP group and non-CAP group after PSM (Table 1). The gene discussed is BCHE; the disease is cerebrovascular disorder.