More details in the realm of cardiomyopathy, including Barth syndrome (a mitochondrial dysfunction disorder caused by mutations in the tafazzin (TAZ) gene), have been identified using Zinc Finger Nucleases (ZFNs), Transcription activator-like effector nuclease (TALEN technology) or CRISPR/Cas9 gene-editing strategy.24,25. Here, TAFAZZIN is linked to cardiomyopathy.