In another study, inhibiting several genes function including Apolipoprotein E (ApoE), cluster of differentiation 36 (CD36), LDL receptor, leptin, and ryanodine receptor type 2 (RyR2) using RNA-guided Cas9 nucleases were represented.33 A mice model of DMD enhanced skeletal muscle function 4 weeks after IM-adeno-associated virus–9 (AAV9)-Cas9 injection.34 The gene discussed is APOE; the disease is Duchenne muscular dystrophy.