Diabetes mellitus (DM), as one of the most common metabolic disorders, is characterized by hyperglycemia and comes from defects in the insulin secretion by the pancreas and insulin resistance in the end-organ tissues or both.1 The prevalence of DM is growing in the world and it is estimated to reach up to 693 million by 2045.2 Chronic hyperglycemia results in damage and disrupted functions of multiple organs especially, eyes, kidneys, nervous and cardiovascular systems. This evidence concerns the gene INS and diabetes mellitus.