The gene expression analysis revealed that expression of Bax was almost doubled (P< 0.001) by the induction of diabetes in the rats (D group), as shown in Figure 1A, but treatment of animals with low or high doses of curcumin or metformin significantly suppressed evaluation of Bax gene expression in treated rats in D + Cur50, D + Cur150, D + Met300, and D + Met500 groups (P< 0.001 for all). The gene discussed is BAX; the disease is diabetes mellitus.