The therapeutic potential of curcumin in the treatment of diabetic cardiomyopathy is probably mediated through several mechanisms such as attenuation of oxidative stress and modulation of Sirt1-Foxo1 and PI3K-Akt pathways12 and by regulation of calmodulin-dependent protein kinase II (CaMKII) and peroxisome proliferator-activated receptor gamma (PPAR-γ) expression.8 Here, PPARG is linked to diabetic cardiomyopathy.