IL6 and PFAPA syndrome: To assess the role of different therapies for PFAPA patients, including tonsillectomy, prebiotics (such as Streptococcus salivarius K12, Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2), colchicine and other conventional disease modifying anti-rheumatic drugs (cDMARDs), small molecules and anti-interleukin(IL)-1/anti-IL-6 biologic agents