This study has the following advantages: (1) this study is the first comprehensive study to investigate the role of TREM-1 expression in the diagnosis and prognosis of neonatal sepsis; (2) meta-regression analysis and subgroup analysis were used to explore the heterogeneity caused by non-threshold effect; (3) sensitivity analysis was used to evaluate the stability of the results of TREM-1 expression in the diagnostic and prognostic value of neonatal sepsis. The gene discussed is TREM1; the disease is Neonatal sepsis.