Considering that Beclin1 is a key molecule involved in autophagy, we further evaluated autophagy flux in epilepsy and observed that the ratio of LC3-II to LC3-I was decreased, while p62 accumulated in epileptic mice, these findings are consistent with previous research (Li et al., 2018) suggesting an activation in autophagy flux rather than the impairment of autophagy. This evidence concerns the gene SQSTM1 and epilepsy.