HOTAIR and central nervous system cancer: Studies have shown that HOTAIR promotes development of glioma by inhibiting Mir-326 and further promoting the expression of fibroblast growth factor 1 (FGF1), which plays a significant carcinogenic role in tumorigenesis by activating the MEK1/2 and PT3K/AKT pathways (Hadari et al., 2001; Ke et al., 2015).