HOTAIR and central nervous system cancer: Downregulation of the expression of miR-326 was observed in glioma specimens and glioma cell lines (U87 and U251), which correlated negatively with the pathological grade of glioma Studies have shown that HOTAIR inhibits miR-326 and promotes the expression of the fibroblast growth factor 1 (FGF1) to promote the development of glioma.