HGF and glioblastoma: The Wnt/β-catenin RAS/MAPK PI3K/Akt and STAT pathways which belong to downstream signal transduction medium of HGF/MET signal can enable to mediate a variety of behaviors of glioblastoma cells, including the progression of the cell cycle, invasion, dryness, angiogenesis, migration, drug-resistant, and recurrence (Zhang Y. et al., 2018; Figure 5).