HGF and glioblastoma: The humanized anti-HGF monoclonal antibody YYB101 can inhibit the growth of tumors in vitro and in situ mouse model of human glioblastoma (Kim and Heo, 2021), Importantly, it can downregulate effective factors of cell molecular including such as p-FAK, p-met, Ki-67, pGab1, MMP2, and uPA/plasminogen (Kim H. K. et al., 2017).