In patients with temporal lobe epilepsy, a subset of neurons in the subiculum in the hippocampus displayed depolarizing up to excitatory GABAergic response that correlated with decreased KCC2 expression and upregulation of NKCC1 (Cohen et al., 2002; Palma et al., 2006; Huberfeld et al., 2007; Muñoz et al., 2007; Moore et al., 2017). Here, SLC12A2 is linked to temporal lobe epilepsy.