This study showed that the levels of BPA and RBP4 were significantly increased in gestational diabetes mellitus, gestational hypertension, intrahepatic cholestasis of pregnancy, gestational anemia, and preterm delivery; the hypothyroidism group had higher urinary BPA and serum RBP4 levels than the normal control group, which indicated that the levels of urinary BPA and serum RBP4 in a pregnant female with clinical hypothyroidism were significantly increased; the increase of BPA and RBP4 is the risk factor of subclinical hypothyroidism during pregnancy in the nonobese female. This evidence concerns the gene RBP4 and gestational diabetes.