High expression of MMP-2 predicts the risk of continuous growth, invasion, and metastasis of AML patients, according to the results of this study of three groups of patients after treatment vWF antigen levels are reduced, but the vWF antigen levels and the incidence of complications with increasing risk classification and corresponding increase, the reason may be due to the high degree of high-risk patients with tumor progression, and AML cells stimulate vascular endothelial cells release a lot of vWF and make high blood coagulation state. This evidence concerns the gene VWF and acute myeloid leukemia.