DAPK1 and hepatocellular carcinoma: Zhang et al. (2012) found that SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells. However, decreasing DAPK1 can alleviate SB203580-induced autophagy. Understanding specific mechanisms through which DAPK1 affects liver cancer progression could lead to new treatment options. In this study, we analyzed changes in gene expression profiles in liver cancer after DAPK1 was knocked out (Xiang et al., 2020). These results may help explain the specific role of DAPK1 in liver cancer (Gozuacik et al., 2008).