IL10 and viral load: Currently, several other molecular mechanisms of ADE that aggravate viral diseases have been recognized, including intrinsic ADE which results in heightened virus production by inhibition of type 1 interferon and activation of interleukin-10 biosynthesis, thereby favoring a Th2-type immune response (Narayan and Tripathi, 2020), immune enhancement ADE (Hotez et al., 2020), complement-mediated ADE (Prohászka et al., 1997), and ADE via host immune suppression by the intracellular virus (Chareonsirisuthigul et al., 2007).