Interleukin (IL)-6, TNF-α, and IL-12(P40), which have generally been recognized as pro-inflammatory factors in DSS-induced colitis, are activated by antigen-presenting cells to perturb the balance of helper T cells and regulatory T cells (Wallace et al., 2014; Ramos and Papadakis, 2019). The gene discussed is IL6; the disease is colitis.