DTNBP1 and schizophrenia: Endocytosis, specifically clathrin-mediated endocytosis (CME), is involved in the pathophysiology of schizophrenia which is based on the evidence that dysbindin, a candidate gene for schizophrenia, was linked to CME.104 Dysfunction in the synapses, changes in the white matter and impaired neurodevelopment are affected by CME in schizophrenia.