Th1 and specialized Th17 cells are liable for the secretion of the cytokines Interferon gamma (IFN-γ) and IL17, which leads to the neuronal inflammation.33 TLR3 induces NF-kB pathway through the expressed TRIF protein for the secretion of type 1 IFNs.34 IFN-β represents a distinct type-1 IFN which is reliably used for the treatment of relapsing-remitting MS, upon the cognitive stimulation of innate immune responses.35 Here, IFNG is linked to relapsing-remitting multiple sclerosis.