Recently, Bruton’s tyrosine kinase (BTK) inhibitors have been reported to play a major role in the radiosensitization of PCa.17 Similarly, B-cell receptor (BCR) pathways were also reported to be involved in the implication of multiple signal transduction pathways, which include modifiable, survival, activation, proliferation, and segregation of B lymphocytes (hematopoietic cells).18-22 Ibrutinib (Ibr), a BTK inhibitor, involves inhibition of multiple tyrosine kinase receptors, which is proven by in vitro cell line and in vivo xenograft studies in various cancer models like LnCaP and DU145. This evidence concerns the gene BCR and posterior cortical atrophy.