Also, similar studies reveal that human PCa cells and mutations in the BTK gene lead to B cell deficiency which further exhibited X-linked gamma globulinemia in humans, X-linked immune deficiency in mice from multiple organs as well.20 The Ibr comprises good potential as radio-sensitizing effects for ‘BTK-BCR’s signaling pathways.18,19 Furthermore, Ibr binds to Cys481 of BTK, thereby inhibits kinase activity in the prostate gland.23 Generally, it also inhibits autophosphorylation activity, PLCg2 activation, enzyme inactive conformation and other downstream substrates of BTK in B cells.24-26. Here, BTK is linked to B cell deficiency.