Moreover, the primary risk factor of PCa is associated with increased levels of sex hormone-like testosterone (T), dihydrotestosterone and decreased levels of plasma level in sex hormone binding globulin,6-9 the cause behind these are believed to be life style changes, food habits (obesity) and genetic factors, which encompasses mechanism variations due to life style changes, food habits (obesity) and genetic factors.10-16. This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.