ERBB2 and cancer: Cancer cells with HER2+ feature found in more than 30% cancer cases.31 Human Epidermal Growth Factor Receptor-2 (HER2) is a notable tyrosine kinase receptor responsible for the progression, proliferation, and metastasis of cancer.32,33 Regarding these results, whether CCA-1.1 modulates the HER2 signaling to inhibit cell growth will be the exciting focus for further research.