In solid tumors, the TME consists of various cellular and molecular components that reduce the immune response’s strength against the tumor.22 TME prevents the proper function of CAR-T cells by decreasing penetration of CAR-T cells and compromising anti-tumor activity.23,24 Cytokines such as TGF-β and IL-10 are developed by TME tumor cells. This evidence concerns the gene TGFB1 and neoplasm.