If this inhibitory factor is removed, it can increase T cells’ proliferation and improve T cells’ effectiveness against cancer cells.51,52 Koretzky and colleagues have also demonstrated that DGKs elimination increases the activity of CAR-T cells against the tumor and stabilizes engineered cells targeting mesothelin receptors.53 CAR-T cells against MSLN could be effective against adenocarcinoma of the pancreatic duct. Here, MSLN is linked to cancer.