As well, up-regulation of the peroxisome proliferator-activated receptors γ (PPAR-γ), LXR-α, ABCA1, and ApoE genes, was observed in C6 glioma cells.55 as well, one of the PPAR-γ)’s (as a nuclear receptor) target gene is LXR-α.56 This evidence concerns the gene NR1H3 and central nervous system cancer.