Indeed, by reducing UCP2 expression in IPF (myo)fibroblasts, we were able to not only reduce senescence but also lower the apoptosis susceptibility of these recalcitrant cells, a strategy that may prove more effective to induce fibrosis regression in established disease (Horowitz & Thannickal, 2019). Here, UCP2 is linked to idiopathic pulmonary fibrosis.