After the intersection of the genes selected by LASSO and SVM‐RFE algorithms, eight genes (CCNDBP1, CDC42SE1, ERCC5, HES6, PCSK1N, PTGDS, RAB2A and RORA) were identified by the mentioned two algorithms simultaneously (Fig. 4D) and were regarded as the optimal candidate features for classification CAD diagnosis. The gene discussed is CDC42SE1; the disease is coronary artery disorder.