The present study aimed to detect coronary artery disease (CAD)‐correlated biomarkers and the regulatory pathways through weighted co‐expression network analysis; we identified three genes (i.e. ERCC5, HES6 and RORA) capable of distinguishing CAD from the control and report that immune‐correlated gene sets were correlated with each other, thereby presenting novel possibilities for early CAD diagnosis and prevention. Here, HES6 is linked to coronary artery disorder.