After the intersection of the genes selected by LASSO and SVM‐RFE algorithms, eight genes (CCNDBP1, CDC42SE1, ERCC5, HES6, PCSK1N, PTGDS, RAB2A and RORA) were identified by the mentioned two algorithms simultaneously (Fig. 4D) and were regarded as the optimal candidate features for classification CAD diagnosis. Here, ERCC5 is linked to coronary artery disorder.