Three molecular biomarkers, namely oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2), along with the proliferation index (Ki-67), are currently used, together with traditional parameters (e.g., tumour size, histological grade, and lymph node involvement), in the routine clinical management of BC patients to choose the appropriate treatment and to predict prognosis and tumour response to therapy [1–3]. This evidence concerns the gene ERBB2 and breast cancer.