Of note, previous findings from MalariaGEN [12, 15, 18–22] and prior studies [10, 11] have proven that the HBB gene is the major genetic risk factor for malaria, and rs334 is an SNP from HBB. Thus, the proposed algorithm with LR-RFE can be considered a promising method, where it can identify rs334 with a higher importance score compared to the benchmark algorithm. The gene discussed is HBB; the disease is malaria.