HBB and malaria: This is an important result because previous findings from MalariaGEN [12, 15, 18–22] and prior studies [10, 11] have proven that the HBB gene is the major genetic risk factor for malaria, and rs334 is an SNP from HBB. Hence, the proposed feature extraction algorithm with LR-RFE appears to be a promising method to extract the significant contributing risk factors to malaria.