By comparing to the previously described pan-cancer immune subtypes in PanImmune29, we found TME3 was specifically associated to PanImmune2 (i.e. the IFN-γ dominant subtype), consistent with the high proportions of INF-γ-producing NK (C25) and T (C14) subtypes in TME3-related tumors (Fig. 7a). This evidence concerns the gene IFNG and cancer.