Inhibition of the CAV-1/NF-κB axis through CAV-1 knockdown could markedly reduce the severity of LPS-induced ALI by promoting the autophagy-related pathway, AMPK, and by inhibiting the activation of the AKT/mTOR pathway and the inflammatory response caused by the infiltration of CD4/80+ macrophages and CD3+ T lymphocytes. This evidence concerns the gene AKT1 and acute respiratory distress syndrome.