In an effort to identify the mechanisms by which IRF6 controls breast cancer cell anoikis we used spontaneously immortalized anoikis-susceptible human non-malignant breast epithelial cells MCF10A and their anoikis-resistant derivative MCF-ErbB2 generated by infection of MCF10A cells with the wild type ErbB2-encoding retrovirus [16]. Here, IRF6 is linked to breast carcinoma.