Furthermore, a detailed study of hippocampal NFT composition found hippocampal pathology can aid in differentiation of CTE and AD as the CA2/CA3 and CA4 subregions of the hippocampus are more severely affected than the CA1 region in CTE, while AD cases show more p-tau pathology in the subiculum and CA1 region [23]. Here, MAPT is linked to Alzheimer disease.