However, one 58-year old male (current smoker and alcohol consumer) with a T1 (N0 M0) microinvasive tonsillar tumour might have been considered spuriously as having a bad prognosis by applying this combined test strategy, as his tumour would have been classified as a HPV-unrelated case, being p16(INK4a) negative while actually both DNA and mRNA HPV16 positive. The gene discussed is CDKN2A; the disease is tonsil neoplasm.