ASXL1 and chronic myelogenous leukemia, BCR-ABL1 positive: There are several genes recurrently mutated at AP/BP, including ASXL1, RUNX1, and IKZF1. In a study enriched for TKI non-responders, mutations were detected in 30% of CML patients in CP (n = 90), and 11/20 patients who progressed to BP had somatic variants at CP [41].