PTEN and breast cancer: Among the known breast cancer-related tumor suppressor genes, we found PTEN deletions in CMGTs of all subtypes, TP53 deletions in basal-like and luminal B tumors and TP53 amplifications in a few tumors of the HER2-enriched and luminal A subtypes, while deletions of CDKN2A (p16) was mostly seen in basal-like CMGT, similarly to human breast cancer [28].