PAK1 and craniodiaphyseal dysplasia: PAKs are in fact critical regulators of cytoskeleton dynamics underlying neuronal morphological changes and plasticity and, in particular, the Thr‐212 phosphorylation site of PAK1 has been proposed to affect the cross‐talk between microtubules and microfilaments during the forward movement and turning of neuronal growth cones,17 a process that was shown to be deranged in CDD neurons.51