Male sex, history of ascites, albumin levels, Child‐Pugh score, MELD score, ALP/ULN, GGT/ULN, ALT/ULN, AST/ULN and total bilirubin, were significantly associated with a reduced probability of biochemical response to OCA therapy according to Poise criteria (Table 2). The gene discussed is ALB; the disease is Ascites.