Recent evidence in autopsy cases showed that in cardiomyocytes from autopsied and explanted hearts of T2DM, the higher expression levels of glycosylated ACE2 (GlycACE2) compared to non-T2DM subjects were attributable to non-enzymatic glycation of four lysine residues in the neck domain of ACE2 [14]. This evidence concerns the gene ACE2 and type 2 diabetes mellitus.