Remarkably, the urinary levels of both Ang 1–9 and Ang 1–7 decreased only in T2DM patients with poor glycemic control at follow-up, indicating a causal relationship between the activity of ACE2 and high glucose levels, likely through the occurrence of non-enzymatic glycosylation of ACE2 protein. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.