However, regression analysis showed that progressive decreases of ANG 1–7, ANG 1–9, and MasR in T2DM recipients were independent of the immunosuppressive state, including covariables such as polyclonal anti-lymphocyte antibodies, cyclosporine, tacrolimus, mycophenolate mofetil, everolimus, and prednisone. The gene discussed is ANGPT1; the disease is type 2 diabetes mellitus.