ANGPT1 and type 2 diabetes mellitus: Furthermore, our data suggest that RAS inefficiency begins early in transplanted healthy hearts of T2DM but not in non-T2DMrecipients, as proved by increase of GlycACE2, NFAT, and fibrosis and decrease of Ang 1–7, Ang 1–9, and MasR already after 12-months from HTX but not during the first EMBs after HTX.