In comparison with region-specific genomic datasets such as Qatar and GME, we found that the variations KCND3:p.L450F and KCNE2:p.I57T were enriched in the Qatar and GME datasets as compared to the IndiGenomes dataset indicating a higher genotypic prevalence of Brugada syndrome-associated risk alleles in the Middle East. The gene discussed is KCND3; the disease is Brugada syndrome.