YAP1 and coloboma: Associated phenotypes include isolated ocular coloboma with variable penetrance or coloboma with sensorineural hearing loss, cleft lip/palate, and learning difficulties [22]; however, YAP1 gene deletion has been reported in a healthy subject [23], and review of our internal SNP microarray dataset (> 21,000 individuals) revealed two other healthy subjects harboring heterozygous deletions of the YAP1 gene (data not shown).