We noted that several genes on chromosomes 4 and 11 have been associated with craniosynostosis, including FGFR3, WDR19, PPP3CA, SEC24D, SOX6, ALX4, and B3GAT3. Analysis of the mRNA gene expression or protein levels of these genes in the relevant patient cells compared to control samples in combination with ccRE analysis may be revealing for her craniosynostosis phenotype. The gene discussed is ALX4; the disease is craniosynostosis.