APP and Alzheimer disease: To date, more than twenty-four dominantly inherited Alzheimer disease (DIAD) pathogenic variants have been reported in Latin American (LatAm) countries, including twenty-one PSEN1, two PSEN2, and one APP variant, with unique characteristics including the presence of common ancestors, evidence of a high grade of admixture and ancestry background (e.g., African, Western European, Asia, and Native American) and presence in large extended families following regional distribution usually related to founder effects [11].