Genetic determinants of AD include pathogenic variants in the amyloid precursor protein (APP), presenilin 1 (PSEN1), or presenilin 2 (PSEN2) genes leading to dominantly inherited AD (DIAD) [10, 11], and susceptibility loci harboring alleles that modify the risk of developing the disease [12, 13]. This evidence concerns the gene PSEN2 and Alzheimer disease.