In 2019, the Dominantly Inherited Alzheimer Network (DIAN), an international network designed to follow families with mutations in APP, PSEN1, and PSEN2 that cause DIAD, launched the DIAN-LatAm initiative to identify new DIAD families from LatAm countries and offer research opportunities and experimental therapies to prevent, delay or treat AD. This evidence concerns the gene PSEN2 and Alzheimer disease.