In 2019, the Dominantly Inherited Alzheimer Network (DIAN), an international network designed to follow families with mutations in APP, PSEN1, and PSEN2 that cause DIAD, launched the DIAN-LatAm initiative to identify new DIAD families from LatAm countries and offer research opportunities and experimental therapies to prevent, delay or treat AD. The gene discussed is APP; the disease is Alzheimer disease.