SOD1 and amyotrophic lateral sclerosis: Founder mutations for ALS have been established in Italians (SOD1: D124G and G41S) [19–21], North American (SOD1: A4V) [22], Polish (SOD1: L144S) [23], Brazil (VAPB: P56S) [24] and Germany (SOD1: R115G) [25].