TARDBP and amyotrophic lateral sclerosis: To further test whether all the cases carrying the mutation were inherited from the same ancestor, we genotyped the eight microsatellite markers (D1S450, D1S244, D1S2736, D1S1151, D1S2667, D1S489, D1S434, D1S2697) flanking the TARDBP gene in the 16 cases carrying the G298S mutation, 92 sporadic ALS cases not carrying the mutation and 65 age-matched neurologically normal individuals (Table 2).