IGF1R and colorectal carcinoma: Consistent with the TCGA study, IGF-1R protein overexpression was associated with the depth of invasion, Dukes’ stage, lymph node metastasis, and distant metastasis in patients with CRC (all P < 0.05, Table 2), and with the increase in Dukes’ stage, the expression level of IGF-1R protein increased significantly (Fig. 3H, Table 2).