In agreement with the TCGA study, CRC (n = 60), colorectal adenoma (n = 30), and adjacent normal tissues (n = 10) and their clinicopathological data were selected, and the expression and distribution of IGF-1R and Livin proteins in various intestinal mucosal tissues was detected, and the correlation between IGF-1R and Livin expression and clinicopathological parameters, occurrence, development, and clinical prognosis of CRC patients was analyzed. The gene discussed is IGF1R; the disease is colorectal adenoma.