A significant correlation was established between IGF-1R gene expression and clinicopathologic features, including age (61–80 years), gender (male), histological subtype (adenocarcinoma), individual cancer stages (stage 3), nodal metastasis status (N1 and N2), and TP53-mutant (Fig. 3A-E and G). Here, TP53 is linked to adenocarcinoma.