For example, Hsa_circ_0003823, which is down-regulated in cirrhotic HCC is also significantly down-regulated in breast cancer tissue and may be involved in inhibiting carcinogenesis [51]; and hsa_circ_0043462, derived from ERBB2, is up-regulated in cirrhotic HCC tissues, as well as in various cancers, and thus functions as a tumor promoter. The gene discussed is ERBB2; the disease is hepatocellular carcinoma.